Dostinex contains the active ingredient Cabergoline; The drug is indicated for the treatment of disorders of Prolactin secretion. The drug Dostinex or Cabergoline is a derivative of the ergot fungus (ergot de seigle) and a rather selective agonist of dopamine D2 receptors, a potent inhibitor of prolactin secretion from the hypothalamus (hypophyse).
Dostinex can also be used to treat infertility in women with hyperprolactinemia.
What is Prolactin?
Prolactin (PRL), also known as the luteotropic hormone or luteotropin, is a protein that plays a role in allowing mammals to produce milk.
They are secreted from the pituitary gland for eating, mating, estrogen treatment, ovulation, and nursing. Prolactin also plays an essential role in metabolism, regulation of the immune system, and pancreatic development.
Dostinex 0.5mg Cabergoline treatment of infertility in women with high Prolactin or tumors of the pituitary gland.
Dosage increases: Your doctor may increase the dose by 0.25mg. This decision depends on your prolactin level. Your doctor may increase your dose every 4 weeks.
Maximum dose: 1mg twice per week.
Children: safety and efficacy have not been established.
Vaginal dose with Dostinex
Women: There are reports that a 0.5 mg vaginal dose 2 to 5 times per week may be effective for normalizing prolactin levels for those who cannot tolerate the dopamine agonist oral dose. Use the lowest dose required for symptom control.
Side effects of dostinex 0.5mg : nausea, headache, dizziness, constipation, weakness, fatigue, abdominal pain and drowsiness.
How to use Dostinex pills
Take DOSTINEX by mouth with or without food, usually twice a week or as directed by your doctor.
The dosage is based on your medical condition and response to treatment (prolactin level). Your doctor will start with a low dose and slowly increase the dose over a few months to help reduce side effects. Follow your doctor's instructions carefully.
Take DOSTINEX regularly to get the most benefit from it. To help you remember, mark the dates on the calendar when you need to take DOSTINEX.
Tell your doctor if your condition persists or worsens.
Dostinex 0 5mg Cabergoline for antibiotic therapy with high Prolactin (2)
Advice from a specialist at Hanoi University of Medicine and Pharmacy
You should not use DOSTINEX if you are allergic to it or if you have:
Uncontrolled high blood pressure (hypertension);
Heart valve disorders;
Growth of excess tissue (fibrosis) in the lungs or around your heart or stomach;
Are allergic to any ergot medicine, such as dihydroergotamine, ergotamine, ergonovine, or methylergonovine.
Tell your doctor if you have ever:
Liver failure ;
Cardiovascular problems;
Pregnancy-induced hypertension, including eclampsia and pre-eclampsia;
It is not known whether cabergoline active ingredient will harm an unborn baby. Tell your doctor if you are pregnant or if you become pregnant.
You should not breast-feed while using DOSTINEX.
What to do in case of overdose?
Call 911 or go to the nearest local Medical Station right away.
Of course, you need to keep a record and bring a list of all the medications you have taken, including prescription and over-the-counter medications.
What to do if I miss a dose?
If you miss a dose of DOSTINEX, take it as soon as possible.
But if it is almost like the next dose, skip the missed dose and take your next dose at the time as planned.
Do not take double the prescribed dose.
Prolactin levels under normal physiological conditions
Normal levels of prolactin in healthy human blood: normal non-pregnant women and healthy men are as follows:
In normal, non-pregnant, healthy adult women, the level of prolactin in the blood is 127-637 µU / mL, in pregnant women it is 200-4500 µU / mL, and in menopausal women 30-430 µU / mL; in normal men, it is 98-456 µU / mL.
Blood prolactin levels change markedly during a day, gradually increasing during sleep, and peaks in the morning. Prolactin in the blood has a biological half-life of only about 20-30 minutes. So, the best time to have a blood drawn for a prolactin test is about 3-4 hours after waking up.
The level of prolactin in the blood can also rise in a number of normal physiological conditions such as: after a meaty meal, after intercourse, nipple stimulation, after exercise, or under stress.
In pregnant and lactating women, the level of prolactin in the blood physiologically increases.
How to maintain a stable concentration of Prolactin
Prolactin levels affect the levels of sex hormones - estrogen in women and testosterone in men. The effects of high Prolactin levels in women can decrease estrogen levels, reducing libido. High prolactin also prolongs recovery time after sex.
In fact, high Prolactin causes the neurotransmitter Dopamine to be reduced, the signals cannot be transmitted to other neurons, which directly affects mood in the negative direction. In contrast, Dopamine is a Prolactin inhibitor. In addition, high prolactin may impair your fertility.
However, there are medications that help lower levels of prolactin like Cabergoline and bromocriptene, but it's rife with side effects like nausea, constipation, dry mouth, and heart palpitations. If you do intend to use the drug, consult your doctor.
Side Effects of Dostinex
Get emergency medical help if you have any of these signs of an allergic reaction after taking DOSTINEX medicine: hives; shortness of breath; swelling of your face, lips, tongue, or throat.
Stop using DOSTINEX and call your doctor at once if you have a serious side effect such as:
Feeling short of breath during exertion;
Discomfort in the chest, dry cough;
Feeling weak or tired, loss of appetite, rapid weight loss;
May faint;
Backache;
Urinating less than usual or at all;
Swelling in ankles or feet.
Less serious side effects while taking DOSTINEX may include:
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects.
Dostinex 0 5mg Cabergoline for antibiotic therapy with high Prolactin (3)
Warnings when taking DOSTINEX drug
Do not use DOSTINEX when hypersensitive to any ingredient or patient with liver, heart, or lung disease. Exercise caution in patients with uncontrolled hypertension or pre-eclampsia; eclampsia or a history of allergic reaction to ergot drugs such as migergot; ereimar.
For pregnant & lactating women
Pregnant women:
Pregnant patients should not use DOSTINEX.
It is advisable to have a contraceptive plan before taking the drug, to use safe anti-change measures. Talk to your doctor immediately if you become pregnant while taking the medication.
You should only become pregnant for at least 1 month after stopping taking the drug
Breastfeeding women:
Women who are breast-feeding should not use DOSTINEX because it inhibits the mother's milk production.
Health status
Your medical condition may affect your use of DOSTINEX. Tell your doctor if you have any other health problems, especially:
Fibrotic disorder (scar-like tissue in the heart, lungs, or stomach), or a history of;
Heart problems (for example, valvular heart disease), or history;
Increased blood pressure, uncontrolled. Not recommended if you have these conditions.
Heart disease;
Lung disease or other breathing problems;
Controllable hypertension;
Hypertension during pregnancy, or a history of;
Liver failure.
Drug Interactions Dostinex
Dostinex's cabergoline active ingredient may interact with other medications that make you sleepy that may exacerbate this effect. Check with your doctor before taking an opioid, sleeping pill, muscle relaxer, or medicine for anxiety or seizures.
Tell your doctor about all other medicines you use, especially
Metoclopramide;
Medicines to treat anxiety, mood disorders, or mental illness such as schizophrenia.
This list is not exhaustive. Other drugs may affect the active ingredient cabergoline, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed here.
How to store the drug Dostinex
You should store the drug at room temperature, dry, avoid direct sunlight exposure.
You should not store the medicine in the refrigerator.
Keep medicine out of reach of children.
You do not throw DOSTINEX in the toilet or plumbing line.
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