How much does Revolade 50mg Eltrombopag treat thrombocytopenia? | ThuocLP Vietnamese Health
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What is Revolade?
The drug Revolade contains the active ingredient Eltrombopag; drugs belong to a group of drugs called thrombopoietin receptor agonists. The drug is used to increase the number of platelets in the blood of adults with chronic immune thrombocytopenia (ITP).
The active ingredient Eltrombopag in the drug is also used to increase platelet counts for people with chronic hepatitis C virus infection, so they can use interferon to treat infections.
It is also used to treat adults with severe aplastic anemia (SAA) when other treatments are ineffective.
The drug Revolade 50mg Eltrombopag treats thrombocytopenia
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Revolade 50mg Eltrombopag Treatment for Treatment (6)
Indications for drug treatment
Revolade is used in patients with chronic thromboembolism (ITP) who are 1 year or older who cannot tolerate other treatments (e.g. corticosteroids, immunoglobulins).
Use in adult patients with chronic hepatitis C (HCV) for the treatment of thrombocytopenia, where the degree of thrombocytopenia is a major factor preventing the initiation or limiting the ability to maintain optimal interferon-based therapy
The drug is indicated for adult patients with severe unexplained anemia (SAA) who could not tolerate prior immunosuppressive therapy or received severe treatment and are not suitable for hematopoietic stem cell transplantation. .
Contraindications to the use of drugs
Hypersensitivity to eltrombopag or to any of the excipients of Revolade.
Dosage and usage of the drug Revolade 50mg
Dosage of the drug Revolade for chronic immune thrombocytopenia
Adults
Initial dose: 50 mg once a day.
Maximum dose: 75 mg once a day.
Children (from 1 - 5 years old)
Initial dose: 25 mg once daily.
Maximum dose: 75 mg once a day.
Dosage changes: Your doctor will check your blood each week to check if this medicine is working for you. Based on your platelet count, your doctor will either increase or decrease your dose.
Dosage of the drug Revolade for low platelet counts from chronic hepatitis C
Adults
Revolade starting dose: 25 mg once daily.
Maximum dose: 100 mg once a day.
Children
It has not been confirmed that the drug is safe and effective when used in people under 18 years of age for this condition.
Dosage drug Revolade for refractory severe aplastic anemia
Adults
Initial dose: 50 mg once a day.
Maximum dose: 150 mg once a day.
Children
It has not been confirmed that this drug is safe and effective when used in people younger than 18 years for this condition.
The first dose for severe aplastic anemia
Adult n
The starting dose of Revolade 150 mg once daily for 6 months.
Children
Children (6-11 years old): Initial dose: 75 mg once daily for 6 months
Children (2 - 5 years old): An initial dose of 2.5 mg / kg once daily for 6 months.
Dosage changes: Your doctor will check your blood regularly to check if this medicine is working for you. Based on your platelet count, your doctor will adjust your dosage.
Special dosage considerations when taking Revolade
For people with mild to severe liver disease: A typical starting dose is 25 mg once daily.
For people of Asian origin: A typical starting dose is 25 mg once daily.
Revolade 50mg Eltrombopag Treatment for Treatment (2)
How to use the drug Revolade
Use the drug according to the dosage and prescription of your doctor.
The drug is taken by mouth, usually once per day or as directed by your doctor. Drink on an empty stomach, 1 hour before meals or 2 hours after meals.
Take the medicine at least 2 hours before or 4 hours after taking any product containing magnesium, aluminum, or calcium. These products bind to eltrombopag, preventing its complete absorption.
Advice from a specialist at Hanoi University of Medicine and Pharmacy
Note that the efficacy and safety of Revolade has not been established for use for other conditions of thrombocytopenia including chemotherapy-induced thrombocytopenia and myelodysplastic syndrome (MDS).
Patients should be cautious and inform their doctor if they are experiencing some of the following conditions:
Use with caution in patients with liver disease; cirrhotic patients.
Use caution in patients with known risk factors for thromboembolism.
What to do in case of overdose drug Revolade?
Call 911 or go to the nearest local Medical Station right away.
Of course, you need to keep a record and bring a list of all medications you have taken, including prescription and over-the-counter.
What to do if I miss a dose?
If you forget to take a dose, take it as soon as possible.
But if it is almost like the next dose, skip the missed dose and take your next dose at the time as planned.
Do not take double the prescribed dose.
Side effects of the drug Revolade
Revolade can cause mild or serious side effects. Serious side effects such as:
The risk of blood clots is higher due to sudden vascular markers;
Liver problems marked with yellow skin or eyes, unusually dark urine;
Decreased platelet count;
Bleeding in the digestive system is marked by black stools, vomiting blood, blood in your stool.
Common side effects can occur :
Diarrhea;
The lens is opaque in the eye;
Unusual hair loss;
Skin rash;
Pain in the muscle or back area or pain in the arms or legs;
Hand tingling or numbness;
Heavy menstruation;
Mouth sores;
Difficulty sleeping;
Itching, runny or stuffy nose, sore throat;
Urinary system infection;
Meningitis;
Irregular heartbeat;
Increased blood sugar (glucose);
Change the enzyme controlling blood clotting;
Increased levels of liver enzymes or bilirubin or certain proteins may appear in blood tests.
Side effects are less common with Revolade
Disruption of blood supply to part of the heart;
Sudden difficulty breathing;
Hematoma;
Sore throat and discomfort when swallowing, pneumonia, sinus, tonsils, nose and throat;
Influenza pneumonia;
Loss of appetite;
Swollen joint pain caused by uric acid (gout);
Sleep problems, depression, lack of interest, changes in mood;
Migraine;
Ear pain, feeling of rotation (dizziness);
Rectal cancer;
Kidney problems;
The amount of blood decreased;
Changing the composition of the blood changes uric acid levels, calcium and potassium;
Generally feeling unwell, a high temperature, feeling hot, or have chest pain;
Pain when urinating.
Some people may experience side effects other than those listed. Check with your doctor if you notice any symptoms that worry you while you are taking Revolade medicine.
Warnings before using the drug Revolade 50mg
These factors may affect how you should use this medication:
Change blood cells: the drug Revolade 50mg stimulates the cells in the bone marrow to produce platelets as well as other blood cells. Sometimes this causes changes in the blood cells or bone marrow that can increase the risk of bone marrow cell disorders and blood cancer.
Blood clots: This medication may increase your risk of forming a blood clot, causing a decrease in blood flow to your organs or extremities.
Cataracts: Revolade pills have been reported to cause cataracts or worsen them for people who had had the onset of cataracts prior to taking the drug.
Dizziness: The drug may cause dizziness, affecting the ability to drive a vehicle or operate machinery. Avoid these and other dangerous tasks until you have determined how this medicine affects you.
Hepatitis C infection: People with chronic hepatitis C infection may have an increased risk of liver failure and death while being treated with interferon and ribavirin.
Kidney function: Kidney disease or decreased kidney function may cause this drug to be ineffective.
Liver function: liver disease or decreased liver function may cause this drug to accumulate in the body, causing side effects. Revolade pills can impair liver function and may cause liver failure.
For pregnant & lactating women
Pregnancy: This drug should not be used during pregnancy unless the benefits outweigh the risks. If you become pregnant while taking this medicine, contact your doctor immediately.
Breast-feeding: It is not known if the active ingredient eltrombopag present in Revolade passes into breast milk. If you are a nursing mother and are taking this medicine, it may affect your baby. Talk to your doctor about whether you should continue breastfeeding.
Other drug interactions with drugs Revolade 50mg
Increased side effects from other drugs: Taking it with certain drugs increases your risk of side effects from these drugs. Examples of these drugs include:
Bosentan, ezetimibe, glyburide, olmesartan, repaglinide, rifampin, valsartan, imatinib, irinotecan, thigh Your doctor may reduce the dosage of these drugs if necessary.
Cholesterol-lowering drugs such as rosuvastatin, atorvastatin, fluvastatin, pitavastatin, Pravastatin, and simvastatin. Increased side effects may include muscle pain. Your doctor may reduce the dose of cholesterol.
When used with Revolade, these drugs can make eltrombopag less effective. This means it will not work as well to treat your condition. This is because the amount of eltrombopag in your body may be decreased. Examples of these drugs include:
Antacids, vitamins, or supplements that contain calcium, aluminum, iron, selenium, zinc, or magnesium. To avoid interactions, you should take eltrombopag two hours before or four hours after taking any of these products.
Interaction with food
Foods containing calcium can make Revolade less effective. These foods include dairy products, such as milk and cheese.
Take the medicine at least two hours before eating calcium rich foods, or four hours after eating calcium rich foods.
Storage of Revolade 50mg
You should store the drug at room temperature, dry, avoid direct sunlight exposure.
You should not store the medicine in the refrigerator.
Keep medicine out of reach of children.
You do not throw medications in the toilet or plumbing pipes.
Revolade 50mg Eltrombopag Treatment for Treatment (3)
Note: The information in the above article onRevoladerelated to its effects and its use for the purpose of sharing knowledge and introducing drug information for medical staff and patients to refer. Depending on the situation and the location, there will be a separate prescription and treatment. Patients are not allowed to arbitrarily use drugs, all information on drug use must be prescribed by professional doctors.
Disclaimer: It is ThuocLP Vietnamese Health's goal to provide readers with relevant and up to date information. However, because drugs interact differently from person to person, we cannot guarantee that this information includes all possible interactions. This information is not a substitute for medical advice. Always talk with your doctor or health care provider about possible interactions with all prescription medications, vitamins, herbs, and over-the-counter supplements and medications you are taking.
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