Imatinib is a medicine that contains the active ingredient imatinib. This drug works by inhibiting the growth of abnormal cells in the diseases listed below. These include some types of cancer.
Imatinib is a treatment for adults and children because:
Chronic myelogenous leukemia (CML). Leukemia is a cancer of the white blood cells. These white blood cells often help the body fight infections. Chronic leukemia is a form of leukemia in which certain abnormal white blood cells (called myeloid cells) begin to grow uncontrollably.
Philadelphia volumetric acute phase lymphoid leukemia (Ph-positive ALL). Leukemia is a cancer of the white blood cells. These white blood cells often help the body fight infections. Acute lymphoblastic leukemia is a form of leukemia in which certain abnormal white cells (named lymphoblasts) begin to go out of control. Imatinib inhibits the growth of these cells.
Imatinib is also a treatment for adults:
Myelodysplastic / myeloproliferative transport disorders (MDS / MPD): These are a group of blood diseases in which some blood cells begin to grow out of control. Imatinib inhibits the growth of these cells in a certain subtype of these diseases.
Hypereosinophilic syndrome (HES) or chronic plasma eosinemia (CEL): These are blood diseases in which some blood cells (named eosinophils) start to lose control. Imatinib inhibits the growth of these cells in a certain subtype of these diseases.
Gastrointestinal lymphoma (GIST): GIST is a type of cancer of the stomach and intestines. It arises from uncontrolled cell growth of the supporting tissues of these organs.
Dermatofibrosarcoma protuberans (DFSP). DFSP is a cancer of the tissue underneath the skin in which some cells begin to go out of control. Imatinib inhibits the growth of these cells.
If you have any questions about how Imatinib works or why this medicine has been prescribed for you, ask your doctor.
Warnings and precautions
Talk to your doctor before taking Imatinib:
If you have or have ever had liver, kidney or heart disease.
If you are taking levothyroxine because your thyroid has been removed.
If you have had or may have hepatitis B. This is caused by Imatinib
get hepatitis B active again, which can be fatal in some cases. Patients will be carefully examined by their doctor for signs of this infection before starting treatment.
If any of these apply to you, tell your doctor before taking Imatinib.
During treatment with Imatinib, tell your doctor right away if you gain weight very quickly. Imatinib can cause your body to seriously retain water.
While you are taking Imatinib, your doctor will often check to see if it is working. You will also have blood tests and be weighed regularly.
Children and adolescents
Imatinib is also a treatment for children with CML. There is no experience in children with the following CML
2 years old. There is little experience with children with Positive Spell and very limited experience in children with MDS / MPD, DFSP, GIST and HES / CEL.
Some children and teenagers taking Imatinib may have slower than normal growth. The doctor will monitor the growth at regular visits.
Other Medicines and Imatinib
Tell your doctor or pharmacist if you are taking, have recently taken or may take any other medicines, including over-the-counter medicines and including herbal medicines. Some drugs can interfere with the effectiveness of Imatinib when taken together.
They may increase or decrease the effectiveness of Imatinib, either lead to increased side effects or make Imatinib less effective. Imatinib may do similar to some other medicines.
Tell your doctor if you are using medicines that prevent the formation of blood clots.
Pregnancy, lactation and fertility
If you are pregnant or breast-feeding, think you are pregnant or are planning to have a baby, consult your doctor before taking this medicine.
Imatinib should not be taken during pregnancy unless clearly needed as it may harm your baby. Your doctor will discuss with you the possible risks of taking Imatinib during pregnancy.
Women who could become pregnant should use effective contraception during treatment.
Do not breast-feed while being treated with Imatinib.
Patients concerned about fertility while taking Imatinib should consult their doctor.
Drive and use the machine
You may feel dizzy or drowsy or see blurred vision while taking this medicine. If this happens, do not drive or use any tools or machinery until you feel well.
Imatinib Imatinib 400mg Tablet for Cancer Treatment (2)
Imatinib dosage
Use in adults
Your doctor will tell you exactly how many tablets of Imatinib to take.
If you are being treated for CML:
Depending on your condition, the usual starting dose is 400 mg or 600 mg:
400 mg taken as once a day,
600 mg taken as one 400 mg tablet plus 2 100 mg tablets once daily.
If you are being treated for GIST:
The starting dose is 400 mg, to be taken as one tablet once a day.
For CML and GIST, your doctor may prescribe a higher or lower dose depending on how you respond to treatment. If your daily dose is 800 mg (2 tablets), you should take one pill in the morning and a second tablet in the evening.
If you are being treated for ALL PH positive:
The starting dose is 600 mg to be taken as one 400 mg tablet plus 2 100 mg tablets once daily.
If you are being treated for MDS / MPD:
The starting dose is 400mg to be taken as one pill once a day.
If you are being treated for HES / CEL:
The starting dose is 100 mg, to be taken as a 100 mg tablet once a day. Your doctor may decide to increase the dose to 400 mg in one 400 mg dose, depending on how you respond to treatment.
If you are being treated for DFSP:
Dosage of 800mg per day (2 tablets), to be taken as one tablet in the morning and a second tablet in the evening.
Use in children and adolescents
The amount of Imatinib given will depend on your child's condition and the doctor will provide the appropriate dosage such as body weight and height.
The total daily dose in children should not exceed 800mg with CML and 600mg with Ph ALL. The treatment can be given to your child as a once-daily dose or alternatively the daily dose can be divided into two vaccinations.
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