Imatinib Imatinib drug for cancer treatment | ThuocLP Vietnamese Health

 

Imatinib Imatinib 100mg for the treatment of leukemia

• Trade Name: Imatinib 100mg.
• Active ingredient: Imatinib.
• Content: 100mg.
• Preparation form: Film-coated tablets.
• Packing: Box of 6 blisters x 10 tablets.
• Manufacturer: Novartis.
• Imatinib drug prices: COMMENTS below for pricing OR Click on the link: https://thuoclp.com/chatFB type “Glivec”.

Imatinib Imatinib Oral Capsule 100mg for Cancer Treatment (5)

What is Imatinib?

Imatinib is a medicine that contains the active ingredient imatinib. This drug works by inhibiting the growth of abnormal cells in leukemia, blood disorders, and cancer.

Indications for treatment of Imatinib 100mg

Adults and children

• Adult and newly diagnosed patients with chronic myelogenous leukemia the Philadelphia chromosome (Ph + CML) in the chronic stage.
• Patient has Ph + CML during blast crisis (BC), accelerated phase (AP) or in chronic period (CP) after failure of interferon-alpha therapy.
• Adult patients with acute or recurrent lymphoblastic leukemia (Ph + ALL).
• Pediatric patients with a newly diagnosed Philadelphia chromosome acute lymphoblastic leukemia (Ph + ALL) in combination with chemotherapy.

Adults

• The adult patient with myelodysplastic / myeloproliferative disease (MDS / MPD) involved in platelet-derived growth factor receptor (PDGFR) gene rearrangement was determined by an FDA-approved test.
• Adult patient with active systemic mastocytosis (ASM) without c-KIT D816V mutation as determined with FDA approved assay or unknown c-KIT mutation
• Adult patient with hypereosinophilic syndrome (HES) or chronic eosinophilic leukemia (CEL) with fusion kinase FIP1L1-PDGFRα and for patients with HES or CEL is FIP1L1-PDGFR
• Adult patient with dermatofibrosarcoma protuberans unable to resect, recur, or metastasize (DFSP)
• Patients with GI stromal tumor caused by KIT (CD117) that cannot be operated on or has spread to other parts of the body
• Postoperative adult patient removed GIST hypothetical KIT (CD117)

The mechanism of action of the substance Imatinib

• The active ingredient in Imatinib is a protein-tyrosine kinase (TKI) inhibitor. This means that it blocks certain enzymes called tyrosine kinase.
• These enzymes can be found in a number of receptors on the surface of cancer cells including receptors that are involved in stimulating cells to divide uncontrollably.
• By blocking these receptors the drug helps to control cell division.

Dosage and administration of Imatinib

Recommended dose in adults

Your doctor will tell you exactly how many tablets of Imatinib to take.

Treatment for CML:

Depending on your condition, the usual starting dose is 400 mg or 600 mg:

• 400 mg taken as once a day,
• 600 mg taken as one 400 mg tablet plus 2 100 mg tablets once daily.

Treatment for GIST:

• The starting dose is 400 mg, to be taken as one tablet once a day.

For CML and GIST, your doctor may prescribe a higher or lower dose depending on how you respond to treatment. If your daily dose is 800 mg (2 tablets), you should take one pill in the morning and a second tablet in the evening.

Treatment for ALL PH positive:

• The starting dose is 600 mg to be taken as one 400 mg tablet plus 2 100 mg tablets once daily.

Treatment for MDS / MPD:

• The starting dose is 400mg to be taken as one pill once a day.

Treatment for HES / CEL:

• The starting dose is 100 mg, to be taken as a 100 mg tablet once a day. Your doctor may decide to increase the dose to 400 mg in one 400 mg dose, depending on how you respond to treatment.

Treatment for DFSP:

• Dosage of 800mg per day (2 tablets), to be taken as one tablet in the morning and a second tablet in the evening.

Recommended dose in children and adolescents

• The doctor will tell you how many capsules of Imatinib to give to your child. The amount of medication given will depend on your child's condition, body weight and height.
• The total daily dose in children should not exceed 800 mg with CML and 600 mg with Ph ALL. The treatment can be given to your child as a once-daily dose or alternatively the daily dose can be divided into two vaccinations.

How to use:

The drug should be used exactly as prescribed by the doctor. You should not increase or decrease the dose on your own, even if you have impaired medical condition.

If you take more Imatinib than you should

If you have accidentally brought too many pills, talk to your doctor right away. You can seek medical attention. Bring the pack of medicine with you.

If you forget to take Imatinib

• If you miss the dose, take it as soon as you remember. However, if it is almost time for the next dose, skip the missed dose.
• Then continue with your normal schedule.
• Do not take a double dose to make a forgotten dose.

If you have any further questions about using this medicine, ask your doctor, pharmacist or nurse.

Imatinib Imatinib Drug 100mg for Cancer Treatment (2)

Instructions for drug use

• Take Imatinib with a meal. This will help protect you from stomach problems when taking Imatinib.
• swallow whole with a large glass of water.

If you are unable to swallow pills, you can dissolve them in a glass of water or apple juice:

• Use approximately 200 ml per 400 mg tablet.
• Stir with a spoon until the tablet is completely dissolved.
• Once the pill has dissolved, drink everything in the glass immediately. Traces of the dissolved pill can be left in the glass.

U pipe smoking  for how long?

• Continue taking Imatinib every day for as long as your doctor tells you.

 

Note when using Imatinib

Do not take if you have ever been allergic to imatinib or to any of the other ingredients in this medication.

Tell your doctor if you have ever had any of the following medical problems:

• Kidney or liver problems;
• Heart problems;
• Thyroidectomy has been removed;
• Hepatitis B infection: use of Imatinib for hepatitis B can be active again.

Pregnancy: This medicine may harm your unborn baby. If you need to take medication during pregnancy, your doctor will discuss with you the risks and benefits involved.

Breastfeeding women: imatinib can pass into breast milk. This drug can affect the baby, lactating women is not recommended.

Side effects

Like all medicines, this medicine can cause side effects, although not everyone takes it. They are usually mild to moderate.

Some symptoms of an allergic reaction may include: difficulty breathing, wheezing or difficulty breathing, swelling of the face, lips, tongue, or other parts of the body; rash, itching or hives on the skin.

Some of the side effects can be serious. Tell your doctor right away if you experience any of the following:

Common side effects:

• Rapid weight gain;
• Signs of infection such as: fever, severe chills, sore throat or mouth sores;
• Unusual bleeding or bruising.

Side effects are uncommon

• Chest pain, irregular heartbeat.
• Cough, difficulty breathing, or soreness.
• Light headache, dizziness, or fainting.
• Feeling down, loss of appetite, dark urine, yellow skin or eyes.
• Redness, blemishes on lips, eyes, skin or mouth, peeling skin, fever, red or purple skin rash, itching, burning sensation, pustular appearance.
• Severe abdominal pain, blood in vomiting, stools or urine, black stools.
• Decreased urine output, a feeling of thirst (signs of kidney problems).
• Feeling nauseous with diarrhea and vomiting, stomach pain or fever.
• Headache, weakness or paralysis of limbs, difficulty speaking, sudden loss of consciousness.
• Pale skin, feeling tired and short of breath, and dark urine.
• Eye pain or impaired vision, bleeding in the eyes.
• Pain in the hip or difficulty walking.
• Cold feet and fingers or fingers.
• Sudden swelling and redness of the skin.
• Muscle fatigue and spasm with an irregular heartbeat.
• Stomach pain with a feeling of nausea.
• Muscle spasms with fever, reddish-brown urine, muscle pain or weakness.
• Pelvic pain sometimes includes nausea and vomiting, sudden vaginal bleeding, feeling dizzy or fainting from low blood pressure.

Other side effects when taking Imatinib

• Combination of a severe diffuse rash, feeling sick, fever, high levels of certain white blood cells or yellow skin or eyes with shortness of breath, chest pain, severely reduced urine and colds thirst ... allergic reactions related to treatment.
• Chronic kidney failure.
• Hepatitis B recurrent infection when you had hepatitis B in the past.

Drug interactions

Some drugs and imatinib may interact with each other increasing side effects. These include many drugs that are eliminated from the body by the liver:

• John's wort: An herbal medicine found in many products that you can buy without a prescription
• Paracetamol: a drug found in many common pain relievers and cold medicines (Panadol, Panadeine, Codral, Tylenol) is known to be involved in liver toxicity.
• antibiotics: such as rifampicin, ketoconazole, erythromycin, clarithromycin, itraconazole.
• antivirals: used to treat HIV / AIDS
• dexamethasone: a steroid medicine
• high cholesterol medicine: such as simvastatin
• medicines used to treat epilepsy: such as phenytoin, carbamazepine, phenobarbitone
• warfarin: a drug used to prevent blood clots
• Certain drugs are used to treat mental disorders and depression
• Some medicines are used to treat high blood pressure and heart problems
• cyclosporin

Imatinib Imatinib Oral Capsule 100mg for Cancer Treatment (3)

Note: The information on the above article about Imatinib 100mg relates to its effects and its usage for the purpose of sharing knowledge and introducing information about the drug for medical staff and patients to refer to. Depending on the situation and the location, there will be a separate prescription and treatment. Patients are not allowed to arbitrarily use drugs, all information on drug use must be prescribed by professional doctors.

Disclaimer: ThuocLP Vietnamese Health's goal is to provide readers with relevant and up to date information. However, because drugs interact differently from person to person, we cannot guarantee that this information includes all possible interactions. This information is not a substitute for medical advice. Always talk with your doctor or health care provider about possible interactions with all prescription medications, vitamins, herbs, and over-the-counter supplements and medications you are taking.

Author Dr. Tran Ngoc Anh

 Articles are quoted from sources: https://thuoclp.com/san-pham/thuoc-glivec-100mg-imatinib-dieu-tri-ung-thu-gia-thuoc-glivec-100mg/