Lenvima 4mg 10mg Lenvatinib for treatment of liver and kidney cancer | ThuocLP Vietnamese Health

 

Basic Information about the drug Lenvima for treatment of thyroid, kidney, and liver cancers.

• Brand name: Lenvima
• Active ingredient: Lenvatinib
• Content: 4mg, 10mg
• Form: Hard capsule
• Packing: 1 box of 20 tablets
• Prices of Lenvima Medicines: COMMENTS below for prices OR Click on the link: https://thuoclp.com/chatFB type “Lenvima”

What is Lenvima?

Lenvima is a prescription drug used to treat certain types of cancer.

• Lenvima is used to treat differentiated thyroid cancer (DTC), a type of thyroid cancer that can no longer be treated with radioactive iodine and is progressing.
• Lenvima is used together with another drug called everolimus to treat advanced renal cell carcinoma (RCC), a type of kidney cancer, after a course of treatment with another anti-cancer drug.
• Lenvima is used as the first treatment for a type of liver cancer called hepatocellular carcinoma (HCC) when it cannot be removed surgically.

It is not known whether Lenvima is safe and effective in children.

Mechanism of action of Lenvatinib

• Lenvatinib belongs to a group of anti-cancer drugs called anti-cancer drugs, and specifically belongs to a family of drugs called protein kinase inhibitors.
• It is used to treat thyroid cancer that has recurred or metastatic (widespread) or progressed despite radioactive iodine treatment.
• Lenvatinib works by recognizing and binding to certain types of cancer cells. This can slow or stop cancer from growing and dividing.

Dosage and administration of Lenvima

Amount

Thyroid Cancer

• Indicated for local recurrence or metastatic, progressive, radioactive iodine-resistant thyroid cancer (DTC)
• 24 mg (two 10 mg tablets and one 4 mg tablet) per day

Renal cell carcinoma

• Combined with everolimus, indicated for advanced renal cell carcinoma (RCC) following a previous anticancer therapy
• 18 mg (one 10 mg tablet and two 4 mg tablets) plus everolimus 5 mg Per day
• Continue until disease progression or until unacceptable toxicity

Hepatocellular carcinoma

• The first treatment indication of unresectable HCC (HCC)

Dosage is based on actual body weight

• <60 kg: 8 mg per day
• ≥60 kg: 12 mg per day

Continue until disease progression or until unacceptable toxicity

Modify dosage

Reduce the DTC dose

• First time: Reduce to 20 mg Per day
• Second time: Reduce to 14 mg Per day
• Third time: Reduce to 10 mg Per day

Reduce the dose of RCC

• First time: Reduce to 14 mg Per day
• Second time: Reduce to 10 mg Per day
• Third: Reduce to 8 mg per day
• Dosage adjustment of everolimus in RCC: Reduce the dose of lenvatinib before and subsequently the dose of everolimus for adverse reactions of both lenvatinib and everolimus

Reduce the DTC dose

First

• ≥60 kg: Decreased to 8 mg Per day
• <60 kg: Decreased to 4 mg Per day

The second time

• ≥60 kg: Decreased to 4 mg Per day
• <60 kg: Decreased to 4 mg Per day

Third time

• ≥60 kg: Decreased to 4 mg Per day
• <60 kg: Stop

How to use

• Lenvima is usually taken once per day. Follow all directions on your prescription label and read all medication guides or instruction sheets. Use the medicine exactly as directed.
• Take Lenvima at the same time every day, with or without food.

To get a full dose, you may need to take a combination of Lenvima capsules with different amounts of pills (strengths) in them. Follow your doctor's medication instructions very carefully.

• Swallow the capsule whole and do not crush, chew, break, or open it.
• If you cannot swallow the whole capsule, dissolve the capsules in water as follows:
• Measure 1 tablespoon of water or apple juice and pour the liquid into a small cup.
• Place the capsule (whole, not crushed or broken) into the liquid. Use only enough capsules for one dose.
• Allow the capsules to dissolve in the liquid for at least 10 minutes. Then, stir the mixture for at least 3 more minutes.
• Drink this mixture right away. Add a little water or juice to a glass, swirl gently and drink right away.

Lenvima is usually taken until your body no longer responds to the medication.

Side effects of Lenvima

• Get emergency medical help if you have signs of an allergic reaction: hives; shortness of breath; swelling of your face, lips, tongue, or throat.
• Some people who take Lenvima have had a perforation (perforation or tear) or a fistula (an abnormal passageway) in the stomach or intestines. Call your doctor if you have severe stomach pain, or if you feel like choking and gagging while eating or drinking.

Also call your doctor at once if you have:

• severe diarrhea;
• headache, confusion, change in mental state, decreased vision, convulsions (convulsions);
• little or no urinating;
• unusual bleeding (nosebleeds, heavy menstrual bleeding) or any other bleeding will not stop;
• signs of stomach bleeding: bloody or tarry stools, coughing up blood, or vomiting that looks like coffee grounds;
• heart problems: chest pain, pain in your jaw or shoulder, swelling, rapid weight gain, feeling short of breath;
• signs of a blood clot: sudden numbness or weakness, problems with vision or speech;
• liver problems: dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes);
• low calcium levels: muscle spasm or spasm, numbness or a feeling of being teased (around your mouth, or in your fingers and toes); or
• increased blood pressure: severe headache, blurred vision, pressure in your neck or ears, anxiety, nosebleeds.

Your cancer treatments may be delayed or permanently stopped if you have certain side effects. Common Lenvima side effects may include:

• bleeding;
• stomach pain, nausea, vomiting, diarrhea;
• loss of appetite, weight loss;
• abnormal thyroid function tests;
• muscle or joint pain;
• swelling in your hands and feet;
• Mouth Sores;
• rash;
• redness, itching, or peeling of the skin in your hands or feet;
• headache, fatigue; or
• cough, shortness of breath, a hoarse voice.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects.

Lenvima 4mg 10mg Lenvatinib for treating charcoal liver cancer (6)

Exercise caution before taking Lenvima

You should not use Lenvima if you are allergic to lenvatinib. To make sure Lenvima is safe for you, tell your doctor if you have ever had:

• heart disease, high blood pressure;
• a heart attack, heart failure, stroke, or blood clot;
• headache or vision problems;
• bleeding problems;
• perforation (a hole or tear) in your stomach or intestines;
• seizure disorder;
• kidney disease; or liver disease.
• You may need a negative pregnancy test before starting this treatment. Do not use Lenvima if you are pregnant. Use effective birth control to prevent pregnancy while you are using this medicine.
• This medicine may affect fertility (ability to have children) in both men and women. However, it is important to use birth control to prevent pregnancy because lenvatinib can harm an unborn baby.
• It is not safe to breast-feed while you are using this medicine. Also don't breast-feed for at least 1 week after your last dose.

Drug trade is different from Lenvima

• Lenvima can cause a serious heart problem. Your risk may be higher if you also use certain other medicines to treat infections, asthma, heart problems, high blood pressure, depression, mental illness, cancer, or malaria. HIV.
• Other drugs may interact with lenvatinib, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell your doctor about all your current medicines and any medicine you start or stop using.

Author Dr. Tran Ngoc Anh

 Articles are quoted from sources:

https://nhathuoconline.org/thuoc-ung-thu/ung-thu-gan-than/thuoc-lenvima/