Stivarga drug 40mg regorafenib for colorectal cancer

What is Stivarga?
Stivarga contains the active ingredient regorafenib 40mg, a cancer drug that interferes with the growth and spread of cancer cells in the body.
The drug is mainly used to treat colorectal cancer and liver cancer. It is also used to treat a rare type of tumor that can affect the esophagus, stomach, or intestines.
Stivarga 40mg regorafenib for treatment of colorectal cancer, liver cancer
Brand name: Stivarga 40mg
Active ingredient: Regorafenib
Manufacturer : Bayer Germany
Content: 40 mg
Packing: Box of 84 tablets in 3 vials, each bottle of 28 tablets
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Stivarga supplement 40mg regorafenib for long-term cancer (3)
What is Stivarga?
Stivarga (regorafenib) is a cancer medicine that interferes with the growth and spread of cancer cells in the body. The drug stivarga is used to treat colorectal cancer and liver cancer . It is also used to treat a rare type of tumor that can affect the esophagus, stomach, or intestines.
Indications for use of the drug
Treatment of patients with colon cancer, metastases that have been previously treated, or are not considered candidates for fluoropyrimidine-based chemotherapy, an anti-VEGF therapy, and if KRAS is wild, an anti-EGFR therapy.
Treatment of GI stromal patients previously treated with kinase inhibitors w / 2 tyrosine.
Treatment of patients with liver cancer, metastasis has been previously treated.
Dosage of the drug Stivarga 40 mg
The usual adult dosages of Stivarga for colorectal cancer:
Initial dose: 160 mg (four 40 mg) orally once daily for the first 21 days of each 28 day cycle.
Duration of treatment: Continue treatment until the progression of the disease or intoxication is unacceptable.
Usual Adult Dose for Digestive Tumor Glioma:
Initial dose: 160 mg (four 40 mg) orally once daily for the first 21 days of each 28 day cycle.
Duration of treatment: Continue treatment until the progression of the disease or intoxication is unacceptable.
Usual Adult Dosage for Liver Cancer:
Initial dose: 160 mg (four 40 mg) orally once daily for the first 21 days of each 28 day cycle.
Duration of treatment: Continue treatment until the progression of the disease or intoxication is unacceptable.
How to use the drug
Please use exactly as prescribed by your doctor. Follow all directions on your prescription label. Your doctor may sometimes change your dose. Do not take this medicine in larger or smaller amounts or for longer than recommended.
Stivarga is usually taken daily for 3 weeks followed by 1 week of discontinuation. Your doctor will decide how many times you should repeat this treatment cycle.
The drug works best if you take it after a little fat, low calorie powder. Swallow the tablet whole with a full glass of water.
Take the medicine at the same time every day.
While using this medicine, your blood pressure will need to be checked often and you may need frequent blood tests.
If you need surgery, tell the surgeon ahead of time that you are using regorafenib. You may need to stop using the medicine for a short time.
Throw away any unused medicine within 7 weeks of opening the bottle.
What happens if I miss a dose?
Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose.
Do not take a double dose of the missed dose.
What should you do if you miss a dose?
If you forget to take a dose, take it as soon as possible. However, if it is close to the next dose, skip the missed dose and take the next dose at the time as planned. Do not take double the prescribed dose.
Since you will be prescribed and monitored by a doctor, pharmacist or health professional when using the drug, an overdose is unlikely.
Stivarga supplement 40mg regorafenib for long-term cancer (4)
Note before taking the drug Stivarga
You should not use it if use in the past has caused serious bleeding or severe liver problems.
To make sure Stivarga 40mg is safe for you, tell your doctor if you have ever had:
Liver failure;
High Blood Pressure;
Bleeding or clotting disorders;
Heart disease, chest pain;
Patient recently undergone surgery or planning to have surgery.
Do not use if you are pregnant. It can harm an unborn baby.
Use birth control to prevent pregnancy while you are using Stivarga, contraception is recommended for both men and women. Continue using birth control for at least 2 months after you finish treatment.
It is not known whether regorafenib passes into breast milk or if it could harm a nursing baby. You should not breastfeed while using this medicine.
Side effects of the drug Stivarga
Get emergency medical help if you have signs of an allergic reaction to the drug Stivarga: hives; shortness of breath; swelling of your face, lips, tongue, or throat.
Stop using Stivarga and call your doctor at once if you have:
Severe headache, vision problems, confusion, thinking problems;
Convulsions;
Rash, blisters, or severe pain in the palms of your hands or the soles of your feet;
Heart problems - chest pain and severe dizziness, trouble breathing;
Hypertension - severe headache, blurred vision, pounding pounding in your neck or ears;
Liver problems - nausea, vomiting, trouble sleeping, dark urine, jaundice (yellowing of the skin or eyes);
Perforation (a hole or tear) in his or her stomach or intestines - fever with severe abdominal pain or swelling, nausea, vomiting, increased thirst, decreased urination;
Severe bleeding - nosebleeds, heavy menstrual periods or unusual vaginal bleeding, blood in urine, bloody or tarry stools, coughing up blood, bleeding or any that will not stop;
Signs of infection - fever, sore throat, feeling short of breath, cough with phlegm, vaginal itching or discharge, pain or burning with urination, or redness and swelling anywhere in your body.
Your cancer treatments may be delayed or permanently stopped if you have certain medication side effects.
Common side effects of the drug Stivarga may include:
Diarrhea, abdominal pain, loss of appetite, weight loss;
Fever, infection;
Abnormal liver function tests;
Painful mouth or throat, hoarse voice;
Feeling weak or tired.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects.
Will other drugs affect Stivarga Medication?
Sometimes it is not safe to use several drugs at the same time. Some medicines can affect your blood level. Other drugs you take, may increase side effects or make the medicine less effective.
Many drugs can interact with regorafenib. This includes prescription and over-the-counter medications , vitamins, and herbal products. Not all possible interactions are listed in this medication guide.
What drugs may interact with Stivarga?
Drug interactions may alter the ability of drugs to work or increase the effects of side effects. This document does not cover all possible drug interactions.
It is best to write a list of all of the medications you are taking (including prescription drugs, nonprescription drugs and supplements) and show them to your doctor or pharmacist. Do not arbitrarily take drugs, stop or change the dosage of the drug without the permission of your doctor.
Anticoagulants (for example, warfarin) because this drug may increase the risk of bleeding;
Cobicistat, fluconazole, itraconazole, ketoconazole, macrolide antibiotics (e.g. azithromycin, clarithromycin), mifepristone, nefazodone, posaconazole, protease inhibitors (e.g. boceprevir, ritonavir), telithromycin or voriconazole as these drugs can increased risk of side effects from regorafenib;
Carbamazepine, enzalutamide, hydantoins (eg phenytoin), phenobarbital, primidone, rifamycins (eg rifampin) or St. John wort as they can reduce the effectiveness of regorafenib.
What should i avoid while taking Stivarga?
Grapefruit and grapefruit juice can interact with regorafenib and lead to potentially dangerous effects. Avoid the use of grapefruit products while taking the medication.
Avoid taking an herbal supplement that contains St. John at the same time you are taking the drug Stivarga 40mg.
This drug can pass into body fluids (urine, feces, vomit). Caregivers should wear rubber gloves when cleaning up a patient's body fluids, handling contaminated waste or washing or changing diapers. Wash hands before and after removing gloves. Wash soiled clothing and towels separately from other laundry.
How to store drugs
You should store the drug at room temperature, dry, avoid direct sunlight exposure.
You should not store the medicine in the refrigerator.
Keep medicine out of reach of children.
You do not throw medications in the toilet or plumbing pipes.
Stivarga supplement 40mg regorafenib for long-term cancer (5)
The FDA expands the drug stivarga to treat liver cancer
The U.S. Food and Drug Administration (FDA) has expanded the use of stivarga (regorafinib) approved for the treatment of HCC - patients who have stopped responding. with initial treatment with the drug sorafenib.
According to the US National Cancer Institute, about 40,710 people will be diagnosed with liver cancer in 2017 and about 28,920 people will die from these diseases. HCC originates in the liver and is the most common form of liver cancer.
Stivarga is a kinase inhibitor that works by blocking certain enzymes that promote cancer growth. The drug Stivarga is also approved for the treatment of colorectal cancer and digestive ganglion tumors that no longer respond to previous treatments.
Common side effects of the drug include stomach pain, skin reactions, fatigue, diarrhea, decreased appetite, increased blood pressure, infection, fever, weight loss, and nausea. The drug is associated with serious risks, including liver damage (liver toxicity), infection, severe gastrointestinal bleeding ...
The FDA also says that pregnant or lactating women should not take the drug because it can harm a developing fetus or a newborn baby. Women taking stivarga should use an effective birth control for 2 months after taking the last dose.
Note: The information in the above article aboutStivarga 40mgdrugrelated to the effects of the drug and its use for the purpose of sharing knowledge and introducing information about the drug for medical staff and patients to refer Depending on the situation and the location, there will be a separate prescription and treatment. Patients are not allowed to arbitrarily use drugs, all information on drug use must be prescribed by professional doctors.
Disclaimer: It is ThuocLP Vietnamese Health's goal to provide readers with relevant and up to date information. However, because drugs interact differently from person to person, we cannot guarantee that this information includes all possible interactions. This information is not a substitute for medical advice. Always talk with your doctor or health care provider about possible interactions with all prescription medications, vitamins, herbs, and over-the-counter supplements and medications you are taking.
Author Dr. Tran Ngoc Anh