Vfend 200 mg Voriconazole for the treatment of men (4)
Indications for Treatment of Voriconazole
Vfend is a broad-spectrum antifungal drug of Azol group, indicated for the prevention and treatment of fungus in adults and children over 2 years old in the following cases:
Invasive Aspergillus infections, including pulmonary Aspergillus infection, complete, bronchial branches, bone marrow and organs.
Candidiasis in a patient with no leukopenia.
Invasive Candida infection: C.tropicalis, C.glabrata, C.kruisei ... including cases resistant to fluconazole and intraconazole.
Severe fungal infections were caused by Scedosporium spp. and Fusarium spp.
Candidiasis of the esophagus
Acute, life-threatening fungal infections, including mycelium and yeast.
Preventive treatment of fungal infections in high-risk subjects: marrow transplant patients, patients with recurrent leukemia.
Dosage and Administration Vfend 200mg Voriconazole
Recommended starting dose is: 200mg or 400mg, taken 12 hours apart during the first 24 hours.
After the first 24 hours the recommended dose is: 100 mg or 200 mg orally twice daily.
For both starting and maintenance dose, the dose used depends on your body weight and the type of infection.
Prophylactic dose in subjects at high risk of fungal infection: use Vfend 200 at a dose of 9mg / kg twice daily, but not to exceed 350mg x 2 times / day.
Preventive treatment should be initiated on sabbatical and can be maintained for up to 100 days. Prophylactic treatment should be as short as possible depending on the risk of developing an invasive fungal infection (IFI) according to neutrophils or impaired immunity. The prophylactic dose lasts only up to 180 days from implantation in case of continued immunodeficiency or GVHD.
Your dose may be adjusted by your doctor depending on how you respond to voriconazole and the side effects you experience.
Adjust the dose
In patients with mild to moderate hepatic impairment: Use 50% of the recommended dose.
Patients with severe hepatic impairment: No data available.
How to use the drug Vfend
Voriconazole tablets should be taken 1 hour before or 2 hours after a meal.
Vfend pills must be taken 1 hour before or 1 hour after a meal.
Contraindicated for use
Hypersensitivity to any ingredient of Vfend.
Patients with severe hepatic impairment.
Concomitant administration with substrates of CYP3A4, terfenadin, astemizol, cisapride, pimozide or quinidine because increased plasma concentrations of medicinal products can lead to prolonged QT and the rare occurrence of torsion.
Concomitant administration with rifampicin, carbamazepin and Phenobarbital because medicinal products are capable of significantly reducing voriconazole plasma concentrations.
Concomitant administration of the recommended dose of voriconazole with efa-virenz 400mg once daily or higher, or ritonavir (400mg and more twice daily). Because these drugs significantly reduce the plasma voricoazole concentration.
Vfend Precautions and Interactions
Use with caution when using Vfend-200 in patients with a history of hypersensitivity to azole drugs, patients with cardiovascular diseases: arrhythmia, cardiomyopathy.
Patients with moderate and mild liver dysfunction: it is necessary to closely monitor the patient's liver function during the entire period of use, and to shorten the duration of treatment as soon as possible in these patients.
Patients with electrolyte disorders: need evaluation and adjustment before taking the drug.
Interactive
Drugs that may interact with Vfend include: Ergot alkaloids (such as ergotamine, dihydroergotamine), sirolimus, a combination HIV drug (such as efavirenz / emtricitabine / tenofovir ).
Combination drugs that can affect heart rate (QT prolongation) include amiodarone, dofetilide, pimozide, procainamide, quinidine, sotalol, and macrolide antibiotics (such as erythromycin).
Voriconazole may slow the elimination of other drugs from the body such as alpha blockers (alfuzosin, silodosin, tamsulosin), oral contraceptives, cisapride, dronedarone, eletriptan, eplerenone, lurasidone, ranolazine, statins (such as lovastatin, simvastatin). , ticagrelor, tolvaptan. Substances that can affect the elimination of voriconazole from the body include sedatives (mephobarbital, phenobarbital), carbamazepine, enzalutamide, primidone, rifamycins (such as rifabutin, rifampin), ritonavir, alcohol.
Vfend 200 mg Voriconazole for the treatment of men (2)
Caution for pregnant and lactating women
Pregnancy: The drug should not be used during pregnancy, except in the case of a life-threatening emergency and the benefit to the mother outweighs the potential risk to the fetus.
Breast-feeding women: no data available should not be used while breastfeeding. Breastfeeding should be stopped when the mother must use the drug.
Undesirable Effects when using Vfend
Get emergency medical help if you have signs of an allergic reaction: hives, difficulty breathing, swelling of the face or throat, or a serious skin reaction: fever, sore throat, burning eyes, skin pain red, purple, or purple skin rash with blistering and peeling.
Some side effects may occur during the injection. Tell your caregiver right away if you experience dizziness, nausea, lightheadedness, itching, sweating, or chest tightness or difficulty breathing.
Call your doctor at once if you have:
fast or rapid heartbeat, pounding in your chest, shortness of breath and sudden dizziness as you may faint;
kidney problems: little or no urinating, swelling in your legs or ankles, feeling tired or short of breath; or
liver problems: nausea, vomiting, flu-like symptoms, itching, fatigue or jaundice or yellowing of the eyes.
Common Vfend side effects may include:
change of vision;
rash;
headache, hallucinations;
fast heart beat;
nausea, vomiting;
abnormal liver function tests.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects.
Overdose and Treatment
There is no specific antidote for voriconazole overdose. Hemodialysis is beneficial for the removal of voriconazole from the body.
Symptoms of overdose may include: photosensitivity, dilated pupils, eyes closed, drooling, loss of balance while moving, depression, shortness of breath, convulsions, bloating, too tired. If casualty is lethargic or unable to breathe, call emergency medical attention.
If you forget to take the medicine
Add the dose as soon as you remember. However, if the interval with the next dose is too short, skip the missed dose and continue on the dosing schedule. Do not take a double dose to make up for a missed dose.
Diet
Do not eat grapefruit and grapefruit products.
Preservation
Keep the medicine in an airtight container, out of reach of children.
Store at room temperature, in a dry place, away from direct sunlight. Do not keep the medicine in the refrigerator.
Vfend 200 mg Voriconazole for the treatment of men (3)
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Note: The information in the above article on Vfend related to the drug's effects and its use for the purpose of sharing knowledge and introducing information about the drug for medical staff and patients to refer. Depending on the situation and the location, there will be a separate prescription and treatment. Patients are not allowed to arbitrarily use drugs, all information on drug use must be prescribed by professional doctors.
Disclaimer: ThuocLP's goal is to provide readers with relevant and up to date information. However, because drugs interact differently from person to person, we cannot guarantee that this information includes all possible interactions. This information is not a substitute for medical advice. Always talk with your doctor or health care provider about possible interactions with all prescription medications, vitamins, herbs, and over-the-counter supplements and medications you are taking.
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