What is Xeloda 500mg? Drugs Capecitabine - Drug prices Xeloda | ThuocLP Vietnamese Health

 

What is Xeloda?

Xeloda drug contains active ingredient capecitabine 500mg in compressed form; belongs to a group of drugs called antiallergic drugs.

The drug Xeloda is used to treat colon cancer, and breast or colorectal cancer has spread to other parts of the body. Also the drug is often used in combination with other cancer drugs or radiation treatments.

Xeloda 500mg Capecitabine pills treat colorectal cancer, breast cancer, stomach cancer

1. 1. Brand name: Xeloda 500mg
   2. Active ingredient: Capecitabine
   3. Manufacturer: ROCHE
   4. Content: 500mg
   5. Form: Tablets 
   6. Packing: Box of 120 tablets
   7. Price of Xeloda Medicines: COMMENTS below for pricing OR Click on the link: https://thuoclp.com/chatFB type “Xeloda”

Xeloda 500mg Capecitabine for Cancer Treatment (3)

Indications for use of the drug

• Adjuvant treatment of patients after stage III colon cancer surgery.
• Colon or rectal cancer has spread to other parts of the body.
• Treatment of advanced stomach cancer.
• Treatment of patients with metastatic or locally progressive breast cancer following the failure of taxan and anthracycline-containing chemotherapy regimens or anthracycline therapy is not indicated.
• Combine with Docetaxel to treat patients with metastatic or locally progressive breast cancer following failure of cytotoxic chemotherapy. Previous therapy should include an anthracycline.

Contraindications to the use of drugs

• History of serious and undesirable reactions to fluoropyrimidine therapy.
• Hypersensitivity to capecitabine or to any of the excipients of Xeloda.
• Complete deficiency of dihydropyrimidine dehydrogenase (DPD) is known.
• During pregnancy and lactation.
• In patients with severe leukopenia or thrombocytopenia,
• In patients with severe hepatic impairment.
• In patients with severe renal impairment (creatinine clearance less than 30 ml / min),
• Concomitant or recent treatment with Brivudine.
• If there are contraindications to any of the medicinal products in the combination regimen, that medicinal product should not be used.

Xeloda dosage

• Colorectal cancer, breast cancer 1250 mg / m2, 2 times / day (morning, evening) x 14 days, followed by 7 days off.
• Combination treatment: Breast cancer started at 1250 mg / m2, 2 times / day for 2 weeks, combined with docetaxel, then leaves for 1 week at rest;
• Stomach cancer, colorectal cancer 800-1000 mg / m2 / time x 2 times / day x 2 weeks, then 7 days off with Xeloda drug or 625 mg / m2 / time x 2 times / day with interdental treatment profanity.

How to use the drug

• Use medicine according to the instructions and instructions of your doctor.
• Xeloda is taken over a 3 week treatment cycle and you may only need to take it for the first 2 weeks of each cycle.
• The drug Xeloda should be taken with food or within 30 minutes after eating a meal.
• Take the pill with a full glass of water; Do not crush or crush the pill

Advice from a specialist at Hanoi University of Medicine and Pharmacy

You should not take Xeloda if you are allergic to capecitabine or fluorouracil (Adrucil).

To make sure the medicine is safe for you, tell your doctor if you have any of the following conditions:

• People with a metabolic disorder called DPD (dihydropyrimidine dehydrogenase) deficiency.
• Kidney disease;
• Bleeding or blood clotting disorder;
• Liver failure;
• History of coronary artery disease;
• Are taking blood thinners (warfarin, Coumadin, Jantoven).
• Do not use Xeloda if you are pregnant. It can harm an unborn baby.
• Use birth control to prevent pregnancy while you are taking medication whether you are male or female. Tell your doctor if you become pregnant during treatment.
• You should not breast-feed while taking Xeloda.

What to do in case of overdose?

• Call 911 or go to the nearest local Medical Station right away.
• Of course, you need to keep a record and bring a list of all medications you have taken, including prescription and over-the-counter.

What to do if I miss a dose?

• If you forget to take a dose of Xeloda, take it as soon as possible.
• But if it is almost like the next dose, skip the missed dose and take your next dose at the time as planned.
• Do not take double the prescribed dose.

Xeloda 500mg Capecitabine for Cancer Treatment (2)

Side effects of the drug Xeloda 500mg

Get emergency medical help if you have signs of an allergic reaction to Xeloda: hives; shortness of breath; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have:

• High fever;
• Nausea, loss of appetite, eating less than usual, vomiting (more than once in 24 hours);
• Severe diarrhea (more than 4 times per day, or at night);
• Blistering or ulcers in the mouth, red or swollen gums, trouble swallowing;
• Pain, redness, swelling, blistering, or peeling skin in your hands or feet;
• Symptoms of dehydration - feeling very thirsty or hot, unable to urinate, sweating a lot, or hot and dry skin;
• Heart problems: chest pain or pressure, irregular heartbeat, difficulty breathing even with mild exertion, swelling or rapid weight gain;
• Kidney problems: little or no urinating; painful or difficult urination; swelling in your feet or ankles; feeling tired or having trouble breathing;
• Liver problems: nausea, upper stomach pain, itching, tired feeling, loss of appetite, dark urine, clay-colored stools, jaundice;
• Low blood count: fever or other flu symptoms, cough, skin sores, pale skin, easy bruising, unusual bleeding, feeling light-headed, fast heart rate.

Common Xeloda side effects may include:

• Stomach pain or discomfort, constipation;
• Feeling tired;
• Mild skin rash; or
• Numbness or tingling in your arms or legs.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects.

Warnings for pregnant & lactating women

• If you are pregnant or breast-feeding, or may be pregnant or planning to become pregnant, ask your doctor or pharmacist for advice before taking Xeloda.
• Capecitabine tablets should not be taken if you are pregnant or suspect that you are pregnant.
• Do not breast-feed if you are taking capecitabine. It is recommended to use safe methods of contraception while taking the drug.

Warnings for health conditions

Your medical condition may affect the use of Xeloda. Tell your doctor if you have any other health problems, especially:

• Allergy to 5-fluorouracil.
• Severe kidney disease.
• Your body lacks the enzyme dihydropyrimidine dehydrogenase (DPD) - Not recommended in patients with these conditions.
• History of coronary heart disease - May cause worse side effects.
• Dehydration
• Kidney disease, mild or moderate
• Liver disease - Use with caution. May make the condition worse.
• Infections - May decrease the body's ability to fight infections.

Drug interactions Xeloda

Before starting treatment, tell your doctor or pharmacist if you are taking, have recently taken, or may take any other medications. This is extremely important, as taking more than one drug at a time can either reinforce or weaken the effects of Xeloda.

You need to be especially careful if you are taking any of the following medications:

1. Medicine to treat gout (allopurinol),
2. Blood thinners (coumarin, warfarin),
3. Certain antiviral drugs (sorivudine and brivudine),
4. Medicine for seizures or tremors (phenytoin),
5. Interferon alpha,
6. Radiation therapy and certain drugs used to treat cancer (folinic acid, oxaliplatin, bevacizumab, cisplatin, irinotecan),
7. Drugs used to treat folic acid deficiency.

Causes of colorectal cancer

The exact cause of colorectal cancer is not known exactly, however, people with certain risk factors are more likely to develop colorectal cancer than others. Some of the risk factors are as follows:

1. Age: Colorectal cancer usually occurs in the elderly, the older the age (usually from 40 and over), the more likely it is to get it. About 80% of cancer cases are discovered at age over 60.
2. Diet and activity : People who eat a lot of fat, protein, low fiber and fresh fruit are more likely to get sick. Sedentary people, fat people also have a higher risk.
3. History of precancerous lesions: colorectal polyps (especially polyps larger than 2 cm), history of chronic colitis, Crohn's disease, persistent dysentery syndrome.
4. History of cancer: A person who has had colorectal cancer may develop colorectal cancer a second time. Additionally, women with a history of ovarian, uterine (endometrial), or breast cancer have a slightly higher risk of developing colorectal cancer.
5. Family history of cancerous cancer: If someone in the family has diabetes, especially with close blood relationships, the risk of getting the disease with family members increases. However, if there is only one close bloodline person who develops diabetes mellitus at the age of 65, the risk increases only slightly.
6. Genetic status: a family history of genetic syndromes such as familial polyps, inherited non-polyp cancer is tens of times higher risk than a family member who does not have this syndrome.

Scientific information about the drug Xeloda 500mg 

Xeloda 500mg medicine can be used at home. Compared with an intravenous drug treatment that is still being used, the drug makes treatment uninterrupted and patients less likely to be hospitalized. The drug has just been approved by the US Food and Drug Administration (FDA). In the body, when combined with an enzyme, the drug Xeloda turns into 5-FU, a cancer treatment drug that has been used for many years.

The FDA first approved this drug, in May 1998, for the treatment of metastatic breast cancer. The 30-week study by the University of Texas (USA) showed that, compared with the classical method, the therapeutic effect of Xeloda was equivalent, while the side effect was less. The main side effects of the drug are diarrhea, nausea, and vomiting.

Xeloda 500mg Capecitabine for Cancer Treatment (4)

Surgical therapy for colon cancer with Xeloda Medicine (Capecitabine)

• In fact, so far, no drugs have been recognized to work with this disease. The 5-year survival rate after surgery is 90% if the cancer is in the lumen of the intestine. 50% if the cancer has eaten through the intestinal wall, has not eaten the lymph nodes, 30% if the tumor has ingested the lymph nodes and only 10% if the cancer has spread to organs, such as liver and lungs.
• According to Dr. Khoo Kei Siong, senior advisor on oncology and treatment at Gieneagles Hospital (Singapore), surgical removal of the tumor is optimal for this type of cancer and therapies are followed. Valence. The risk of surgery (such as bleeding in connective tissue or infection) is reduced by 50-60% if performed by the surgeon.
• After surgery to remove the tumor, chemotherapy may not be needed. This depends on at what stage the patient is suffering from cancer. In stages II and III of the disease, the patient must receive chemotherapy to increase recovery. In stage IV, chemotherapy works to stop the growth of cancer cells. Do not use radiation therapy for colon cancer because it is easy to cause radiation infection to the organs in the abdomen.
• Recently, there have been new chemotherapy drugs for colon cancer that are not only more effective, but also less negative side effects. Therefore, chemotherapy is the safest method. Oxaliplatin, Irinotecan, Cetuximab (Erbitux) and Acizumab (Avastin) are new effective chemotherapy drugs, some of which do not cause hair loss at all.
• In particular, recently there was the first pill against metastatic colon cancer, called Xeloda (Capecitabine) , with a dose to be taken every 2 days at home. Research at the University of Texas (USA) showed that when entering the body, the drug combines with an enzyme to transform into 5-FU - a cancer treatment drug that has been used for many years. The therapeutic effect of Xeloda is comparable to that of other chemotherapy drugs, while the side effects are minimal, leaving the treatment uninterrupted and the patient not having to be hospitalized.

Watch video xeloda 500mg Capecitabine 
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How to store drugs

• You should store the drug at room temperature, dry, avoid direct sunlight exposure.
• You should not store the medicine in the refrigerator.
• Keep medicine out of reach of children.
• You do not throw medications in the toilet or plumbing pipes.

Note: The information in the above article about Xeloda related to its effects and its usage for the purpose of sharing knowledge, introducing drug information for medical staff and patients to refer. Depending on the situation and the location, there will be a separate prescription and treatment. Patients are not allowed to arbitrarily use drugs, all information on drug use must be prescribed by professional doctors.

Disclaimer: ThuocLP's goal is to provide readers with relevant and up to date information. However, because drugs interact differently from person to person, we cannot guarantee that this information includes all possible interactions. This information is not a substitute for medical advice. Always talk with your doctor or health care provider about possible interactions with all prescription medications, vitamins, herbs, and over-the-counter supplements and medications you are taking.

Author Dr. Tran Ngoc Anh

Articles are quoted from sources: https://thuoclp.com/san-pham/thuoc-xeloda-500mg-120-vien-capecitabine-gia-thuoc-xeloda/