Xarelto contains the active ingredient Rivaroxaban and is used in adults
Prevent blood clots in the veins after hip or knee replacement surgery. Your doctor has prescribed this medication for you because after surgery there is a risk of blood clots.
treat blood clots in the veins of your legs (deep vein thrombosis) and in the blood vessels of the lungs (pulmonary embolism), and to prevent blood clots from re-appearing in the blood vessels of your legs and / or lung.
Xarelto belongs to a group of drugs called antithrombotic drugs. It works by blocking a clotting factor (factor Xa) and thus reducing the tendency for blood to form clots.
Mechanism of action
Rivaroxaban is a highly selective direct factor Xa inhibitor with oral bioavailability.
Inhibition of factor Xa disrupts the intrinsic and exogenous pathways of the clotting flow, inhibiting both thrombin formation and thrombi development.
Rivaroxaban does not inhibit thrombin and has no proven platelet effects.
Rivaroxaban works by binding to the distal clotting factor, and this ultimately reduces the formation of fibrin and makes the blood less likely to clot.
Dosage of Xarelto 10mg
Usual Adult Dose for Deep Vein Thrombosis (Recurrent)
Recommended dose: 10 mg orally once a day
Use: Reduce the risk of recurrence of deep vein thrombosis (DVT) and / or pulmonary embolism (PE) in patients at risk of recurrence of DVT and / or PE after at least 6 months of standard anticoagulant treatment .
Usual adult dose for pulmonary embolism (recurrence)
Recommended dose: 10 mg orally once a day
Use: Reduce the risk of recurrence of deep vein thrombosis (DVT) and / or pulmonary embolism (PE) in patients at risk of recurrence of DVT and / or PE after at least 6 months of standard anticoagulant treatment .
Usual adult dose for prophylaxis of deep vein thrombosis following surgery
Initial dose: 10 mg orally once a day starting 6 to 10 hours after surgery
Duration of treatment
Hip replacement surgery: 35 days
Knee replacement surgery: 12 days
Contraindications to the drug xarelto 10mg Rivaroxaban
Hypersensitivity to the active substance or to any of the excipients.
There is currently any serious bleeding.
Have any condition that increases your risk of bleeding, such as stomach ulcers or certain types of cancer.
Have recently had surgery on your brain, spine, or eyes.
Are taking other anticoagulants to treat or prevent blood clots, like warfarin or heparin.
Have liver and kidney problems.
Have an artificial heart valve.
are pregnant: you need to use an effective birth control to prevent pregnancy while taking Rivaroxaban, as it may harm a developing baby.
are breastfeeding: if you need to be treated with rivaroxaban, you should not breast-feed because we do not know if the drug passes into breast milk.
Xarelto 10mg Rivaroxaban with herbal medicine (3)
Side effects of Xarelto
Like other similar drugs (antithrombotic drugs), Xarelto can cause bleeding that is potentially life-threatening. Excessive bleeding can lead to a sudden drop in blood pressure (shock).
Bleeding can also be a sign of side effects. In some cases, bleeding may not be obvious
Tell your doctor right away, if you experience any of the following side effects:
long or excessive bleeding
exceptional weakness, fatigue, paleness, dizziness, headache, unexplained swelling, difficulty breathing, chest pain or angina, may be signs of bleeding.
Your doctor may decide to keep you under closer observation or change the way you should be treated.
Signs of a serious skin reaction
widespread skin rash, blisters, or mucosal damage, eg in the mouth or eyes (Stevens-Johnson syndrome / toxic epidermal necrolysis). The frequency of this side effect is very rare (up to 1 in 10,000).
a drug reaction that causes rash, fever, inflammation of internal organs, hematological abnormalities, and systemic disease (DRESS syndrome). The frequency of this side effect is very rare (up to 1 in 10,000).
Signs of a severe allergy
Swelling of face, lips, mouth, tongue, or throat; Difficulty swallowing; rash and difficulty breathing; sudden drop in blood pressure.
The frequency of these side effects is very rare (anaphylactic reactions, including anaphylaxis; can affect 1 in 10,000 people) and uncommon (angioedema and allergic edema; may affect 1 in 100 people).
Common side effects (can affect 1 in 10 people)
a decrease in red blood cells can make the skin pale and cause weakness or difficulty breathing
stomach or intestinal bleeding, urogenital bleeding (including blood in urine and heavy menstrual bleeding), nosebleeds, bleeding gums
bleeding into the eye (including bleeding from the whites of the eyes)
bleeding into the body's tissues or cavities (hematoma, bruising)
hemoptisi
bleeding from the skin or under the skin
bleeding after surgery
bleeding or fluid from the surgical wound
swelling in the limbs
pain in the limbs
impaired kidney function
fever
Stomach pain, indigestion, feeling or being sick, constipation, diarrhea
low blood pressure (symptoms may feel dizzy or faint when standing up)
decreased general strength and energy (weakness, fatigue), headache, dizziness
rash, itchy skin
Blood tests can show an increase in some liver enzymes
Uncommon (can affect up to 1 in 100 people)
bleeding into the brain or inside the skull
bleeding into the joint causes pain and swelling
Thrombocytopenia (low platelet count, which are the cells that help blood clot)
allergic reactions, including allergic skin reactions
impaired liver function (can be seen in tests done by your doctor)
Blood tests can show an increase in bilirubin, certain liver or liver enzymes or platelet count
fainting
not feeling well
faster heart rate
Dry mouth
hive
Rare side effects (can affect 1 in 1,000 people)
Bleeding into the muscles
Cholestasis (decreased bile flow), hepatitis included. damage to liver cells (inflammation of the liver including liver damage)
Jaundice (jaundice) is localized swelling
Blood clot (hematoma) in the groin as a complication of cardiac procedure where the catheter is placed into your leg artery (pseudoaneurysm)
If you get any of these side effects, talk to your doctor or pharmacist. This includes any possible side effects not listed in this leaflet.
Other drug interactions with Xarelto
It is important to tell your doctor or pharmacist what medicines you are taking, including those that are over-the-counter and herbal medicines, before you start taking Xarelto.
Check with your doctor or pharmacist before taking any new medicine after you start taking Xarelto, to make sure this combination is safe. Some key points are:
Analgesic
Do not take over-the-counter pain relievers, anti-inflammatory drugs, or cold and flu medicines that contain aspirin, ibuprofen, or naproxen while you are taking Xarelto.
These medications should only be used on the advice of a doctor as they may increase the risk of bleeding.
Herbal
Do not take the herbal medicine St. John'st (Hypericum perforatum) while you are taking Rivaroxaban, as it can make Rivaroxaban less effective in preventing blood clots.
Store Xarelto
Store at room temperature below 30 ° C.
Store in a dry place, do not store in the bathroom.
Keep all medicines in a safe place, out of reach of children and pets.
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