Denosumab denosumab 120mg for cancer spread to increase calcium huyet (2)
Indications for use of the drug
Denosumab Xgeva 120mg is indicated for the treatment of bone problems that may occur with cancer spreading to the bones or for the treatment of high blood calcium (hypercalcemia) that may occur with cancer.
Injectable medications are used to treat osteoporosis in men and women who have gone through menopause, who may not be able to take or respond to treatment with other osteoporosis medications.
The injectable denosumab is also used to treat osteoporosis in men with prostate cancer and in women with breast cancer that are being treated with certain methods that may increase the risk of fractures.
The active ingredient Denosumab is used to reduce fractures from certain types of cancer that start in another part of the body but have spread to the bones. Injectable medications are also used in adults and some teenagers to treat giant cell tumors of the bones (GCTB).
Contraindications to the use of drugs
Hypersensitivity to the active ingredient Denosumab or to any ingredient of denosumab.
Contraindicated to patients with low blood calcium content (hypokalemia) and patients with hypersensitivity to any components of the drug.
Prolia can harm an unborn baby or cause birth defects. Do not use if you are pregnant.
Instructions for using denosumab 120mg
The denosumab is injected under the skin in the biceps, thighs, or abdomen, usually by a doctor or nurse at a clinic or hospital.
When the injectable denosumab is used to treat osteoporosis or to treat osteoporosis in men with prostate cancer and women with breast cancer, it is usually given every 6 months.
The drug is used to relieve fractures caused by cancer that has metastasized in the bone, it is usually given once every 4 weeks.
The drug Xgeva is used to treat giant cell tumors of the bone, it is usually given every 7 days for the first three doses (on day 1, day 8, and day 15) and then once every 4 Week starts 2 weeks after the first three doses.
Your doctor will give you calcium and vitamin D supplements while you are being treated with the injectable denosumab.
Exercise caution before using denosumab
You should not take denosumab if you are allergic to the active ingredient denosumab, or if you have low calcium in your blood (hypokalemia).
While you are using the drug, you should not receive Prolia another brand of denosumab.
To make sure denosumab 120mg is safe for you, tell your doctor if you:
kidney disease (or if you are on dialysis);
a weak immune system (caused by disease or by using certain drugs);
a history of hypoparathyroidism (decreased function of the parathyroid glands);
a history of thyroid surgery ;
a history of surgery to remove part of the intestine;
any conditions that make it difficult for your body to absorb nutrients from food (reduced absorption); or
if you are allergic to latex.
The drug can cause bone loss (bone necrosis ) in the jaw. Symptoms include neck pain or numbness , red or swollen gums, loose teeth, gum infection, or slow healing after dental work.
Osteonecrosis of the jaw may be more likely if you have cancer or receive chemotherapy , radiation, or steroids. Other risk factors include blood clotting disorders, anemia (low red blood cells), and an existing dental problem.
Denosumab can harm an unborn baby or cause birth defects. Do not use Prolia if you are pregnant. Tell your doctor right away if you become pregnant during treatment.
It is not known whether Denosumab passes into breast milk or if it could harm a nursing baby. This drug may also slow breast milk production. You should not breast-feed while taking the drug.
Medication Side Effects
Call emergency medical help if any of these possible side effects : hives , itching, hives; difficulty breathing, feeling light-headed; swelling of your face, lips, tongue, or throat.
Call your doctor at once if you:
new or unusual pain in the thigh, hip, or groin;
severe pain in the joints, muscles, or bones;
skin problems such as dryness, peeling, redness, itching, blisters, bumps, oozing, or sheath; or
Low amount of calcium in the blood (hypokalemia) - numbness or lightness feeling around the mouth or in the fingers or toes, waist or body spasm, excessive reflexes.
Serious infections can occur during treatment with denosumab 120mg. Call your doctor at once if you have signs of infection such as :
Fever , chills, night sweats ;
Swelling, pain, pain, heat, or redness anywhere on the body;
Pain or burning when urinating;
Increased or urgent need to urinate;
Severe stomach pain; or
Cough, shortness of breath.
Common side effects may include:
Bladder infection (painful or difficult urination);
Back pain , muscle pain ;
Pain in your arms or legs.
Drug interaction of denosumab
Before taking denosumab tell your doctor or pharmacist:
If you are allergic to it or if you have any other allergic reaction. This product may contain inactive ingredients, which can cause allergic reactions or other problems.
Medications you are taking, including prescription and over-the-counter medicines, vitamins, supplements, and herbal products, especially cancer medications; immunosuppressants such as azathioprine (Imuran), cyclosporine (Gengraf, Neoral, SANDIMUNE), methotrexate (Rheumatrex, Trexall), sirolimus (Rapamune), and tacrolimus (Prograf); or oral steroids such as dexamethasone (Decadron, Dexpak), methylprednisolone (Medrol), and prednisone (Sterapred); Your doctor may need to change your dose of medication or carefully monitor for side effects
How to store drugs
Store in original box at a temperature between 2 ° C and 8 ° C (36 ° F to 46 ° F). Don't freeze.
Before use, bring room temperature to 25 ° C (77 ° F) in original container (usually takes 15 to 30 minutes); Do not use any other methods to warm.
Use within 14 days at room temperature.
Protect from direct heat and light; Do not expose to temperatures> 25 ° C (77 ° F). Avoid strong vibrations.
Denosumab Xgeva 120mg for cancer spread to increase calcium huyet (5)
Note: The information in the above article on denosumab is related to its effects and its use with the purpose of sharing knowledge, introducing information about the drug for healthcare professionals and patients. Depending on the situation and the location, there will be a separate prescription and treatment. Patients are not allowed to arbitrarily use drugs, all information on drug use must be prescribed by professional doctors.
Disclaimer:ThuocLP's goal is to provide readers with relevant and up to date information. However, because drugs interact differently from person to person, we cannot guarantee that this information includes all possible interactions. This information is not a substitute for medical advice. Always talk with your doctor or health care provider about possible interactions with all prescription medications, vitamins, herbs, and over-the-counter supplements and medications you are taking.
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