What is Geftinat drug? how to take medicine

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 Drug information Geftinat 250mg Gefitinib treatment of lung cancer

  • Brand Name: Geftinat
  • Active ingredient: Gefitinib
  • Content: 250mg
  • Form: Tablets
  • Packaging: 1 box of 30 tablets
  • Producer: Natco
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What is Geftinat 250mg Gefitinib?

Geftinat 250mg active ingredient Gefitinib belongs to a group of anti-cancer drugs. It is a tyrosine kinase inhibitor chemotherapy drug used to treat lung cancer.

Gefitinib is a targeted therapy used to treat locally advanced or metastatic non-small cell lung cancer, following failure of both chemotherapy.

Geftinat is indicated for the treatment of patients with locally advanced or metastatic non-small cell lung cancer (NSCLC) who have previously received chemotherapy or are not suitable for chemotherapy.

How does Gefitinib work?

The active ingredient gefitinib is a selective small-molecule inhibitor of the epidermal growth factor receptor tyrosine kinase and is an effective treatment for patients whose tumors have EGFR tyrosine kinase region-activating mutations regardless of any therapy.
Common EGFR-activating mutations have robust response data supporting sensitivity to gefitinib; for example, progression free heart rate (95% CI) was 0.489 (0.336, 0.710) for gefitinib compared with doublet chemotherapy.
Response data to gefitinib are sparser in patients with tumors harboring less common mutations; available data indicate that G719X, L861Q and S7681 are susceptible mutations; and T790M alone or exon 20 insertion are resistance mechanisms.

Indications and contraindications for treatment of Geftinat

Indications for treatment

It is indicated as monotherapy for the treatment of adult patients with locally advanced or metastatic non-small cell lung cancer (NSCLC).

Contraindications to treatment

  • Hypersensitivity to the active substance or to any of the excipients.
  • breastfeeding women.

Dosage and how to use Geftinat?

Dosage of the drug

  • The recommended dose of Geftinat is 1 tablet of 250 mg/day, taken with or without meals.

How to take medicine

  • The tablet can also be dispersed in a glass of water. Drop the tablet into the water, do not crush, stir until the tablet is completely dispersed (about 10 minutes).
  • Geftinat is not recommended for use in children or adolescents because safety and efficacy have not been studied in this group of patients.
  • No dose adjustment is required for age, body weight, sex, race or renal function or in patients with moderate to severe hepatic impairment due to liver metastases.
  • Dose adjustment: Patients with poorly tolerated diarrhea or skin adverse reactions can be successfully controlled by stopping the drug for a short time (< 14 days) and then reintroducing the dose. 250mg.
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