What is Crizonix drug? how to take medicine

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Drug information Crizonix 250mg Crizotinib for non-small cell lung cancer (NSCLC)

  • Brand Name: Crizonix 250mg.
  • Active ingredient: Crizotinib.
  • Manufacturer: Beacon Pharmaceuticals Limited, Bangladesh.
  • Content: 250mg.
  • Form: Capsules.
  • Packaging: Box of 28 tablets.
  • Quotations Crizonix : direct contact or leave a comment https://thuoclp.com/chatFB type " Crizonix"

What is Crizonix 250mg Crizotinib?

Crizonix contains the active ingredient Crizotinib, which is indicated for the treatment of ROS-1-positive non-small cell lung cancer and NSCLC. The active ingredient is an ALK and ROS-1 inhibitor.

A drug is a cancer drug that helps hinder the growth and spread of cancer cells in the body. The drug is used to treat non-small cell lung cancer. which has spread to other parts of the body.



Mechanism of action of the active ingredient Crizotinib

The active ingredient crizotinib is a selective small molecule inhibitor of ALK receptor tyrosine kinase (RTK) and its oncogenic variants. Crizotinib is also an inhibitor of Hepatocellular Growth Factor Receptor (HGFR, c-Met) RTK, ROS1 (c-ros) and Recepteur d'Origine Nantais (RON) RTK.

Crizotinib demonstrated concentration-dependent inhibition of the kinase activity of ALK, ROS1, and c-Met in biochemical assays and inhibited phosphorylation and the kinase-dependent phenotype upregulated in the assays. cell based.

The active ingredient demonstrated potent and selective growth inhibitory activity as well as apoptosis induction in tumor cell lines expressing ALK fusion events.

The active substance demonstrated antitumor effects, including pronounced cytostatic antitumor activity, in mice bearing tumor xenografts expressing the ALK fusion protein.

The active substance also demonstrated marked antitumor activity in studies in which tumors were generated using a panel of NIH-3T3 cell lines engineered to express important ROS1 fusions identified in human tumors.

What is Crizonix used for?

  • First-line treatment for adults with aggressive non-small cell lung cancer (ALK) positive for adult non-small cell lung cancer (NSCLC).
  • Treatment of adults with previously treated aggressive non-small cell lung cancer (NSCLC).
  • Treatment of adults with ROS1-positive advanced non-small cell lung cancer (NSCLC).

Who should not take Crizonix?

Hypersensitivity to the active substance Crizotinib or to any of the excipients of Crizonix.

Dosage and how to use Crizonix?

Dosage of Crizonix

Usual adult dose for non-small cell lung cancer: 250 mg twice daily until disease progression or unacceptable toxicity.

How to take medicine

 Crizonix is a pill you take twice a day, with or without food. If your doctor prescribes Crizotinib, make sure you:

  • Use medication exactly as prescribed by your doctor.
  • The drug should only be swallowed whole, not crushed.
  • Do not change your dose or stop taking Crizotinib unless your doctor tells you to.
  • Do not drink grapefruit juice or eat grapefruit as long as you are taking medication. It may cause the amount of Crizonix in your blood to rise to harmful levels.
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